SPRAVATO® (esketamine) Nasal Spray


SPRAVATO® nasal spray is a different kind of medication taken with an oral antidepressant for adults with treatment-resistant depression – a first in decades approved by the FDA. SPRAVATO® works differently than other medications to target treatment-resistant depression.

If you’ve struggled with depression and tried two or more antidepressants* in your current episode without adequate relief, talk to us to see if you have treatment-resistant depression.

SPRAVATO® is a prescription medicine, used along with an antidepressant taken by mouth, for treatment-resistant depression (TRD) in adults.

SPRAVATO® cannot be purchased at a pharmacy. To support the safe and appropriate use of SPRAVATO™, it is given at certified SPRAVATO™ treatment centers. This could be a different location than your regular doctor’s office. We are a certified SPRAVATO™ treatment center.

Frequently Asked Questions (FAQ's) on SPRAVATO®

1. What is SPRAVATO?

Spravato is a brand-name prescription medication that’s prescribed for treatment-resistant depression (TRD). TRD is depression that hasn’t improved after treatment with two or more antidepressants.

2. Is SPRAVATO a controlled substance?

Yes, SPRAVATO® is a controlled substance. It’s classified by the FDA as a Schedule Three (III) drug. This means that SPRAVATO is accepted for medical use, but has a high risk of dependence. SPRAVATO has the potential to be misused.

3. What is Treatment- Resistant Depression (TRD)?

TRD is a type of depression that hasn’t improved after you’ve tried at least two different antidepressant medications. Your doctor will determine if you have TRD based on your use of other antidepressants.

4. What is the procedure to use SPRAVATO?

SPRAVATO is administered in-office only. Patients will utilize the nasal spray under supervision. Patients are able to stay in our Spravato room for up to two hours to ensure their comfort and safety. Compassionate Psychiatric Services offers reclining, massage chairs to ensure the experience is as comfortable as possible. We follow COVID-19 CDC guidelines for social distancing and cleaning procedures to ensure the safety of our patients and staff.

5. Where can I find more information about Spravato?

SPRAVATO® (esketamine) CIII Nasal Spray

If you or a loved one are interested in seeing if you are qualified for SPRAVATO® treatments, give our office a call today at 469-200-4093

6. How Spravato works?

SPRAVATO® targets the N-methyl-D-aspartate (NMDA) receptor and is believed to work differently than currently available oral antidepressants. The exact way that SPRAVATO® works are unknown. SPRAVATO® is taken with an oral antidepressant.

7. What should I expect (SPRAVATO)?

You should not expect the treatment on your first visit. You will be able to discuss the REMS program, insurance matters, scheduling and treatment day preparation. You’ll need to plan for rides to and from the certified SPRAVATO® treatment center as you will not be able to drive, operate machinery or do anything where you need to be completely alert until the day after a treatment session, following a restful sleep. You may want to bring a book, a relaxing playlist or another form of entertainment for the session because your healthcare provider will monitor you for at least two hours after treatment.

8. Do you know which significant cities Compassionate Psychiatric Services offer its mental health services to?

Compassionate Psychiatric Services range from anxiety, depression, post-traumatic stress disorder (PTSD), addiction, trauma, eating disorders to numerous other mental health conditions and are offered to all our patients in the following city locations: Dallas, The Colony, Richardson, Flower Mound, Lewisville, Prosper, Irving and Arlington.



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